diff --git a/.changes/next-release/bugfix-AWSSDKforJavav2-238f31f.json b/.changes/next-release/bugfix-AWSSDKforJavav2-238f31f.json
new file mode 100644
index 000000000000..fa5fbf52a05d
--- /dev/null
+++ b/.changes/next-release/bugfix-AWSSDKforJavav2-238f31f.json
@@ -0,0 +1,6 @@
+{
+    "type": "bugfix",
+    "category": "AWS SDK for Java v2",
+    "contributor": "Techno3d",
+    "description": "Fix a bug where an SDK Client that has a plugin which supplies a region would throw an SdkClientException stating that no region was set."
+}
diff --git a/core/sdk-core/src/main/java/software/amazon/awssdk/core/client/builder/SdkDefaultClientBuilder.java b/core/sdk-core/src/main/java/software/amazon/awssdk/core/client/builder/SdkDefaultClientBuilder.java
index 34f165dd1767..1ff44b3e31d4 100644
--- a/core/sdk-core/src/main/java/software/amazon/awssdk/core/client/builder/SdkDefaultClientBuilder.java
+++ b/core/sdk-core/src/main/java/software/amazon/awssdk/core/client/builder/SdkDefaultClientBuilder.java
@@ -202,14 +202,14 @@ protected final SdkClientConfiguration syncClientConfiguration() {
         configuration = mergeChildDefaults(configuration);
         configuration = mergeGlobalDefaults(configuration);
 
+        // Invoke the plugins
+        configuration = invokePlugins(configuration);
+
         // Create additional configuration from the default-applied configuration
         configuration = finalizeChildConfiguration(configuration);
         configuration = finalizeSyncConfiguration(configuration);
         configuration = finalizeConfiguration(configuration);
 
-        // Invoke the plugins
-        configuration = invokePlugins(configuration);
-
         return configuration;
     }
 
@@ -233,14 +233,14 @@ protected final SdkClientConfiguration asyncClientConfiguration() {
         configuration = mergeChildDefaults(configuration);
         configuration = mergeGlobalDefaults(configuration);
 
+        // Invoke the plugins
+        configuration = invokePlugins(configuration);
+
         // Create additional configuration from the default-applied configuration
         configuration = finalizeChildConfiguration(configuration);
         configuration = finalizeAsyncConfiguration(configuration);
         configuration = finalizeConfiguration(configuration);
 
-        // Invoke the plugins
-        configuration = invokePlugins(configuration);
-
         return configuration;
     }
 
diff --git a/test/codegen-generated-classes-test/src/test/java/software/amazon/awssdk/services/SdkPluginTest.java b/test/codegen-generated-classes-test/src/test/java/software/amazon/awssdk/services/SdkPluginTest.java
index f36061fe8583..1b3bd4240582 100644
--- a/test/codegen-generated-classes-test/src/test/java/software/amazon/awssdk/services/SdkPluginTest.java
+++ b/test/codegen-generated-classes-test/src/test/java/software/amazon/awssdk/services/SdkPluginTest.java
@@ -40,6 +40,7 @@
 import java.util.stream.Stream;
 import org.junit.jupiter.params.ParameterizedTest;
 import org.junit.jupiter.params.provider.MethodSource;
+import org.junit.jupiter.api.Test;
 import org.mockito.Mockito;
 import software.amazon.awssdk.auth.credentials.AwsBasicCredentials;
 import software.amazon.awssdk.auth.credentials.AwsCredentialsProvider;
@@ -595,6 +596,15 @@ public void beforeTransmission(Context.BeforeTransmission context, ExecutionAttr
         assertThat(timesInterceptorCalled).hasValueGreaterThanOrEqualTo(1);
     }
 
+    @Test
+    public void pluginSetRegionIsUsed() {
+        ProtocolRestJsonClient client = ProtocolRestJsonClient.builder()
+            .addPlugin(config -> ((ProtocolRestJsonServiceClientConfiguration.Builder) config).region(Region.US_EAST_1))
+            .credentialsProvider(DEFAULT_CREDENTIALS)
+            .build();
+        assertThat(client.serviceClientConfiguration().region()).isEqualTo(Region.US_EAST_1);
+    }
+
     private static ProtocolRestJsonClientBuilder defaultClientBuilder() {
         return ProtocolRestJsonClient.builder().region(Region.US_WEST_2).credentialsProvider(DEFAULT_CREDENTIALS);
     }