diff --git a/.github/workflows/test-sqlite.yml b/.github/workflows/test-sqlite.yml
index a79dcf1..834e8cf 100644
--- a/.github/workflows/test-sqlite.yml
+++ b/.github/workflows/test-sqlite.yml
@@ -29,5 +29,8 @@ jobs:
     - name: Race
       run: go test -v -race ./...
 
+    - name: Race with sqlite_enable_api_armor
+      run: go test -v -race -tags sqlite_enable_api_armor
+      
     - name: No CGO build
       run: CGO_ENABLED=0 go install ./...
diff --git a/cgosqlite/apiarmor_disabled_test.go b/cgosqlite/apiarmor_disabled_test.go
new file mode 100644
index 0000000..4034808
--- /dev/null
+++ b/cgosqlite/apiarmor_disabled_test.go
@@ -0,0 +1,11 @@
+//go:build !sqlite_enable_api_armor
+
+package cgosqlite
+
+import (
+	"testing"
+)
+
+func TestAPIArmorDisabled(t *testing.T) {
+	testAPIArmor(t, false)
+}
diff --git a/cgosqlite/apiarmor_enabled_test.go b/cgosqlite/apiarmor_enabled_test.go
new file mode 100644
index 0000000..1f5b27d
--- /dev/null
+++ b/cgosqlite/apiarmor_enabled_test.go
@@ -0,0 +1,11 @@
+//go:build sqlite_enable_api_armor
+
+package cgosqlite
+
+import (
+	"testing"
+)
+
+func TestAPIArmorEnabled(t *testing.T) {
+	testAPIArmor(t, true)
+}
diff --git a/cgosqlite/apiarmor_test.go b/cgosqlite/apiarmor_test.go
new file mode 100644
index 0000000..76193c2
--- /dev/null
+++ b/cgosqlite/apiarmor_test.go
@@ -0,0 +1,58 @@
+package cgosqlite
+
+import (
+	"path/filepath"
+	"sync/atomic"
+	"testing"
+
+	"github.com/tailscale/sqlite/sqliteh"
+)
+
+// testAPIArmor provides a common function for testing SQLITE_ENABLE_API_ARMOR.
+func testAPIArmor(t *testing.T, wantMisuseError bool) {
+	if wantMisuseError && !APIArmorEnabled() {
+		t.Fatal("APIArmor is not enabled")
+	} else if !wantMisuseError && APIArmorEnabled() {
+		t.Fatal("APIArmor is enabled")
+	}
+
+	var gotMisuseLog atomic.Bool
+	err := SetLogCallback(func(code sqliteh.Code, msg string) {
+		if code == sqliteh.SQLITE_MISUSE {
+			gotMisuseLog.Store(true)
+		}
+	})
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	db, err := Open(filepath.Join(t.TempDir(), "test.db"), sqliteh.OpenFlagsDefault, "")
+	if err != nil {
+		t.Fatal(err)
+	}
+	err = db.Close()
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	// Configuring AutoCheckpoint on a closed database should result in a misuse error
+	// if and only if [APIArmorEnabled] reports true.
+	got := db.AutoCheckpoint(1)
+	if wantMisuseError {
+		if got == nil || got.Error() != "SQLITE_MISUSE" {
+			t.Fatalf("want SQLITE_MISUSE, got %s", got)
+		}
+
+		if !gotMisuseLog.Load() {
+			t.Fatal("did not get SQLITE_MISUSE in LogCallback")
+		}
+	} else {
+		if got != nil && got.Error() == "SQLITE_MISUSE" {
+			t.Fatalf("want no error, got %s", got)
+		}
+
+		if gotMisuseLog.Load() {
+			t.Fatal("got SQLITE_MISUSE in LogCallback")
+		}
+	}
+}
diff --git a/cgosqlite/cgosqlite.go b/cgosqlite/cgosqlite.go
index e5f5d9a..145e370 100644
--- a/cgosqlite/cgosqlite.go
+++ b/cgosqlite/cgosqlite.go
@@ -46,6 +46,15 @@ package cgosqlite
 // libm is required by the FTS5 extension, on Linux.
 #cgo linux LDFLAGS: -lm
 
+// Enable API armor.
+#cgo sqlite_enable_api_armor CFLAGS: -DSQLITE_ENABLE_API_ARMOR
+
+#ifdef SQLITE_ENABLE_API_ARMOR
+int api_armor_enabled=1;
+#else
+int api_armor_enabled=0;
+#endif
+
 #include "cgosqlite.h"
 */
 import "C"
@@ -502,3 +511,8 @@ func stringFromBytes(b []byte) string {
 	internCache.Store(s, s)
 	return s
 }
+
+// APIArmorEnabled reports whether or not sqlite was compiled with SQLITE_ENABLE_API_ARMOR.
+func APIArmorEnabled() bool {
+	return C.api_armor_enabled == 1
+}